There are currently 268 active clinical trials seeking participants for Depression research studies. The states with the highest number of trials for Depression participants are California, New York, Florida and Pennsylvania.
Modified Interactive Screening Program Plus MINDBODYSTRONG: a Mental Health Resiliency Intervention for Nurses
Recruiting
The overall purpose of this study is to evaluate the efficacy of an intervention designed to prevent nurse suicide. This randomized controlled trial will test the modified Interactive Screening Program (mISP) alone and the mISP combined with a program called MINDBODYSTRONG. The mISP is a method of screening to detect clinicians at moderate to high risk for suicide and referring them for treatment through an encrypted anonymous on-line platform. MINDBODYSTRONG© is an adaptation of a well-tested... Read More
Gender:
ALL
Ages:
18 years and above
Trial Updated:
02/04/2025
Locations: The Ohio State University Wexner Medical Center, Columbus, Ohio
Conditions: Suicide Threat, Burnout, Professional, Depression
Incorporating Positive Affect Promoting Activities Into Cognitive Behavioral Therapies
Recruiting
In this study, the investigators will test whether the incorporation of positive affect promoting activities in treatment sessions improves outcomes in the context of CBT for depression and DBT for problems of emotion dysregulation. In clinics focused on each of these treatments, the investigators will evaluate these treatments with and without the addition of positive affect promoting activities.
Gender:
All
Ages:
18 years and above
Trial Updated:
05/24/2024
Locations: Department of Psychology, The Ohio State University, Columbus, Ohio
Conditions: Depression, Borderline Personality Disorder, Emotion Regulation
Ketogenic Intervention in Depression
Recruiting
The goal of this study is to examine whether a well-formulated ketogenic diet (KD) can be implemented into a university counseling treatment program for major depression and to test whether such a program has any benefit on mental and metabolic health.
Gender:
All
Ages:
Between 18 years and 30 years
Trial Updated:
04/01/2024
Locations: The Ohio State University, Columbus, Ohio
Conditions: Depression, Ketosis
Positive Processes and Transition to Health - Single-Session (PATH-SS)
Recruiting
The goal of this clinical trial is to test a brief, new psychotherapy (called Positive Processes and Transition to Health - Single Session, or PATH-SS) that aims to provide relief for people who are suffering after experiencing a sexual assault. This research will explore whether this new psychotherapy reduces sexual assault related distress, including posttraumatic stress and depression symptoms. The main questions it aims to answer are: Does PATH-SS leads to improvements in PTSD and depressio... Read More
Gender:
ALL
Ages:
Between 18 years and 65 years
Trial Updated:
03/22/2025
Locations: Case Western Reserve University, Cleveland, Ohio
Conditions: PTSD, Depression
TEAM-Red, a Remotely Delivered Self-management Program for Depressed Black Women at Risk for Hypertension
Recruiting
The proposed project is a 24-week prospective randomized controlled trial (RCT) evaluating the effects of TargEted MAnageMent Intervention (TEAM, N=41) vs. enhanced waitlist (eWL, N=41) control in young (\<50 years) African American women who are depressed or suffering from stress, and at risk for hypertension.
Gender:
FEMALE
Ages:
Between 18 years and 49 years
Trial Updated:
10/04/2024
Locations: University Hospitals Cleveland Medical Center, Cleveland, Ohio
Conditions: Depression
Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD)
Recruiting
Acute, double-blind, adaptively randomized treatment with duloxetine or escitalopram, followed by double-blind, randomized adjunctive treatment with clonazepam or pregabalin for persistent symptoms.
Gender:
ALL
Ages:
Between 18 years and 50 years
Trial Updated:
08/28/2024
Locations: University of Cincinnati, Department of Psychiatry & Behavioral Neuroscience, Cincinnati, Ohio
Conditions: Anxious Depression, Depression
Lithium Effects on the Brain's Functional and Structural Connectome in the Treatment of Bipolar Disorder
Recruiting
Lithium is highly effective in the treatment of bipolar disorder. This study aims to investigate, for the first time, the impact of lithium monotherapy on the structural and functional connectivity of the brain using MRI imaging.
Gender:
All
Ages:
Between 18 years and 60 years
Trial Updated:
04/05/2024
Locations: Cleveland Clinic Foundation Center for Behavioral Health, Cleveland, Ohio
Conditions: Bipolar Disorder, Bipolar I Depression, Bipolar II Depression, Bipolar Depression, Depression, Major Depressive Episode
CAMPUS Expanded "Classification and Assessment of Mental Health Performance Using Semantics Expanded"
Recruiting
Open enrollment study to collect data for the optimization of machine learning models for use in an app for the early detection of mental health and suicidal risk.
Gender:
All
Ages:
Between 8 years and 75 years
Trial Updated:
02/05/2024
Locations: Clarigent Health, Mason, Ohio
Conditions: Suicide, Suicidal, Suicide, Attempted, Suicidal Ideation, Depression, Anxiety, Aggression, Trauma, Psychological
Mental Health App for Cancer Survivors Study
Recruiting
The goal of this clinical trial is to adapt a mental health digital app to treat depression among head and neck cancer patients and survivors. Participants will download and use the digital mental health app for a 6-week period, and will complete related surveys.
Gender:
ALL
Ages:
22 years and above
Trial Updated:
03/28/2025
Locations: University of Wisconsin Carbone Cancer Center, Madison, Wisconsin
Conditions: Head and Neck Cancer, Head and Neck Cancers, Depression
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
Recruiting
Background: Major depressive disorder (MDD) is a psychiatric condition. People with MDD have occasional bouts of depressive symptoms; these bouts are called major depressive episodes (MDEs). Researchers want to know if people having MDEs have lower levels of an enzyme called PDE4B in their brains. Primary Objective: To determine whether PDE4B is reduced in the brains of individuals with MDD experiencing a major depressive episode (MDE). Secondary Objectives: To determine the optimal length of... Read More
Gender:
ALL
Ages:
Between 18 years and 70 years
Trial Updated:
03/26/2025
Locations: National Institutes of Health Clinical Center, Bethesda, Maryland
Conditions: Depression
Collaborative Care for Anxiety and Depression in Epilepsy
Recruiting
This is a randomized effectiveness/implementation trial comparing a 24-week neurology-based collaborative care intervention to usual neurology care among 60 adults with epilepsy.
Gender:
ALL
Ages:
18 years and above
Trial Updated:
03/26/2025
Locations: Wake Forest University Health Sciences, Winston-Salem, North Carolina
Conditions: Epilepsy, Anxiety, Depression
Brief, High-dose rTMS for Depression
Recruiting
High frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to be safe, feasible, and acceptable. Conventionally, rTMS investigations have relied on rational decision trees for dosage determination. The purpose of this study is to systematically examine an accelerated protocol of intermittent theta burst (iTBS). Study 1 aims to provide a quantifiable dose-response curve for iTBS and depressive symptom reduction in major depression. Study 2 aims to determine the role of indi... Read More
Gender:
ALL
Ages:
Between 18 years and 60 years
Trial Updated:
03/25/2025
Locations: Medical University of South Carolina, Charleston, South Carolina
Conditions: Depression, Anxiety